| Worry |
| Bother |
| Problem |
| Nuisance |
| Big pain |
| Migraine |
| Annoyance |
| Big bother |
| Big problem |
| Cephalalgia |
| Acute problem |
| Inconvenience. |
| Migraine, e.g. |
| Aspirin target |
| Major annoyance |
| Bothersome type |
| Ibuprofen target |
| Vexing situation |
| Hangover symptom |
| Annoying problem |
| Migraine, for one |
| Vexatious problem |
| Pain in the brain |
| Annoying situation |
| Major inconvenience |
| Tylenol target, perhaps |
| Source of worry (and pain!) |
| Annoying person or situation |
| Pain in the butt, ironically |
| One reason for taking aspirin |